01720nas a2200169   4500008004100000022001400041245019400055210006900249260000900318300001400327490000700341520099300348100002501341700002301366700002601389856013501415       2023                        eng d  a0022-326300aPd(II)-catalyzed tandem cycloannulative-alkenylation of o-alkynyl-phenols/anilines with (E)-β-Iodovinyl sulfones: a direct strategy to construct 3-(Vinyl sulfonyl)benzoheterole derivatives0 aPdIIcatalyzed tandem cycloannulativealkenylation of oalkynylphen  cJUN   a8889-89030 v883 a<p>
	Benzoheterolesand vinyl sulfones are the most promisingpharmaceuticalrelevance motifs, yet the hybrid analogues of these scaffolds stillneed to be explored. We report herein a general and highly efficientPd(OAc)(2)-catalyzed intramolecular cyclization and vinylationof o-alkynylphenols/o-alkynylanilineswith (E)-beta-iodovinyl sulfones under mild reactionconditions. A direct C(sp(2))-C(sp(2)) cross-couplingis enabled for the diversity-oriented synthesis of vinyl sulfone-tetheredbenzofurans and indoles in good to high yields with excellent stereoselectivity.Notably, this tandem process was consistent at the gram scale, andin situ, generation of 2-(phenylethynyl)phenol has also been utilizedin a scalable synthesis. Late-stage synthetic transformations werealso further explored, including isomerization and desulfonylative-sulfenylation.Moreover, several control experiments were accomplished, and we proposeda plausible mechanism based on existing experimental results.</p>
1 aReddy, Raju, Jannapu1 aSharadha, Nunavath1 aKrishna, Gamidi, Rama  uhttps://library.ncl.res.in/content/pdii-catalyzed-tandem-cycloannulative-alkenylation-o-alkynyl-phenolsanilines-e-%CE%B2-iodovinyl