01350nas a2200181 4500008004100000022001400041245003900055210003800094260000800132300001400140490000700154520085500161100001901016700001601035700002801051700001801079856007101097 2023 eng d a1477-052000aC-H functionalization of pyridines0 aCH functionalization of pyridines cJUL a5671-56900 v213 a

Pyridine and its reduced form (piperidine) are the most common nitrogen heterocycles in FDA-approved drugs. Additionally, their presence in alkaloids, ligands for transition metals, catalysts, and organic materials with various properties makes them among the most important structural cores. Despite its importance, direct and selective functionalization of pyridine remains scarce due to its electron-poor nature and nitrogen coordination power. Instead, functionalized pyridine rings were primarily constructed from suitably substituted acyclic precursors. The focus on sustainable chemistry with minimum waste generation encourages chemists to develop direct C-H functionalization. This review summarizes different approaches to tackle the reactivity and regio- and stereoselectivity aspects for direct pyridine C-H functionalization.

1 aMaity, Susmita1 aBera, Asish1 aBhattacharjya, Ayantika1 aMaity, Pradip uhttps://library.ncl.res.in/content/c-h-functionalization-pyridines