01140nas a2200193 4500008004100000022001400041245015400055210006900209260000800278300001400286490000700300520040300307100002400710700001800734700002300752700002600775700001500801856013000816 2023 eng d a2052-412900aSynthesis of N-functionalized 2,3-disubstituted benzofurans/naphthofurans from para-quinone methides and isocyanides via the [4+1] annulation pathway0 aSynthesis of Nfunctionalized 23disubstituted benzofuransnaphthof cJUL a3746-37510 v103 a

A scandium triflate catalyzed [4 + 1] cycloaddition reaction of 2-hydroxy-substituted para-quinone methides and isocyanides has been developed. This operationally simple, efficient and practical protocol provides straightforward access to a variety of N-functionalized 2,3-disubstituted benzofuran/naphthofuran derivatives with broad functional group compatibility and good scalability.

1 aKale, Someshwar, B.1 aKumar, Manish1 aShinde, Dinesh, R.1 aKrishna, Gamidi, Rama1 aDas, Utpal uhttps://library.ncl.res.in/content/synthesis-n-functionalized-23-disubstituted-benzofuransnaphthofurans-para-quinone-methides