01350nas a2200157   4500008004100000022001400041245013700055210006900192260000900261300001400270490000700284520072900291100002101020700002401041856012701065       2023                        eng d  a1359-734500aPIDA-mediated N-N bond formation to access pyrazolidine-3,5-diones: a novel process for uricosuric agents G-25671 and sulfinpyrazone0 aPIDAmediated NN bond formation to access pyrazolidine35diones a   cJUN   a8242-82450 v593 a<p>
	Traditionally, toxic and expensive hydrazine building blocks are required to construct pharmaceutically important pyrazolidine-3,5-diones. Herein, we have described a novel method for their synthesis based on metal-free oxidative dehydrogenative N-N bond formation by PIDA-mediated reaction of easily accessible dianilide precursors. The developed mild reaction protocol features a good functional group tolerance and scalability. The application of this method is demonstrated by offering a unique route for the synthesis of uricosuric agents G-25671 and sulfinpyrazone from inexpensive starting material aniline via smooth functionalization of the well-designed diversity-oriented cyclopropyl key intermediate.</p>
1 aHalder, Priyanka1 aMhaske, Santosh, B.  uhttps://library.ncl.res.in/content/pida-mediated-n-n-bond-formation-access-pyrazolidine-35-diones-novel-process-uricosuric