01565nas a2200193   4500008004100000245016700041210007100208260000800279300001600287490000700303520077100310100003001081700002301111700002901134700002401163700002401187700002101211856013901232       2023                        eng d00aOrganocatalysed one-pot three component synthesis of 3,3′-disubstituted oxindoles featuring an all-carbon quaternary center and [spiro 2H-pyran-3,4′-indoline]0 aOrganocatalysed onepot three component synthesis of 33′disubstit  cAPR  a13206-132120 v133 a<p>
	A simple and efficient methodology for the one-pot synthesis of 3,3 `-disubstituted oxindoles featuring an all-carbon quaternary center has been demonstrated through l-proline catalysed three-component reaction based on sequential Knoevenagel condensation/Michael addition and also one-pot synthesis of spiro[2H-pyran-3,4 `-indoline] through consecutive Knoevenagel condensation/Michael addition/reduction/cyclization reactions from readily available isatin derivatives, malononitrile, and ketones. The present methodology presents several advantages, including simple reaction set-up, short reaction times, and easy to work-up. Also, this strategy offers broad substrate scope with excellent yields and high atom economy, under mild reaction conditions.</p>
1 aNichinde, Chandrakant, B.1 aPatil, Baliram, R.1 aChaudhari, Suryakant, S.1 aMali, Bhupendra, P.1 aGonnade, Rajesh, G.1 aKinage, Anil, K.  uhttps://library.ncl.res.in/content/organocatalysed-one-pot-three-component-synthesis-33%E2%80%B2-disubstituted-oxindoles-featuring-all