01362nas a2200157   4500008004100000022001400041245009300055210006900148260000900217300001400226490000700240520079900247100002601046700002301072856010901095       2023                        eng d  a1359-734500aDirect amidation of acids in a screw reactor for the continuous flow synthesis of amides0 aDirect amidation of acids in a screw reactor for the continuous   cJUL   a9231-92340 v593 a<p>
	A simple and efficient solvent-free protocol for continuous flow synthesis of amides at room temperature is developed using easily available starting materials. N-(3-Dimethylaminopropyl)-N &amp; PRIME;-ethylcarbodiimide hydrochloride (EDC.HCl) was used as the reagent for the formation of an amide bond without using any metal catalyst or additives. A jacketed screw reactor when operated over a residence time of 30 300 s helped achieve almost complete conversion. This approach is extended for the synthesis of 36 derivatives and 2 bioactive molecules using different substrates having different aliphatic mono and di-acids as well as aromatic acids, including aromatic hetero-acid compounds and phenyl hydrazine. The target amide was scaled up to 100 g with an average 90% yield.</p>
1 aAtapalkar, Ranjit, S.1 aKulkarni, Amol, A.  uhttps://library.ncl.res.in/content/direct-amidation-acids-screw-reactor-continuous-flow-synthesis-amides