02160nas a2200169   4500008004100000022001400041245014800055210006900203260000800272300001600280490000700296520147700303100002401780700002501804700002501829856013601854       2023                        eng d  a1144-054600aGreen, practical & scalable approach towards the synthesis of valuable α-keto amides using a metal-free catalyst under solvent-free conditions0 aGreen practical scalable approach towards the synthesis of valua  cOCT  a19679-196870 v473 a<p>
	alpha-Ketoamides are very important motifs as they are present in many natural products, drugs &amp; biologically important molecules. We synthesized a very simple, cheap, eco-friendly &amp; reusable glucose-based carbonaceous material (GCM), which showed high performance as a catalyst in the oxidative cross-dehydrogenative coupling (CDC) reaction of alpha-ketoaldehydes with amines for the synthesis of alpha-ketoamides. The GCM catalyst was also very efficient for one-pot two-step synthesis of alpha-ketoamides from alpha-ketoalcohols as well. The GCM catalyst was able to catalyze alcohol oxidation in alpha-ketoalcohols followed by CDC reaction with amines to form alpha-ketoalcohols. The reactions were found to proceed smoothly at a low temperature of 50 degrees C using a green &amp; economical metal-free catalyst under base-free, ligand-free &amp; solvent-free reaction conditions to get the corresponding alpha-ketoamides in good to excellent yields. The results demonstrated that the GCM catalyst showed acidic as well as superior oxidising catalytic activity due to the presence of a carboxylic acid (-COOH) and hydroxyl (-OH)-enriched carbonaceous framework, which enabled the synthesis of important alpha-ketoamide motifs. The applicability of the catalyst was also evaluated for the synthesis of an anti-HIV agent drug molecule. Greener, cheaper &amp; eco-friendly GCM catalyst as well as catalytic process for synthesis of alpha-Keto Amides.</p>
1 aBankar, Shubham, R.1 aGhadge, Sambhaji, S.1 aJadhav, Vrushali, H.  uhttps://library.ncl.res.in/content/green-practical-scalable-approach-towards-synthesis-valuable-%CE%B1-keto-amides-using-metal-free