01549nas a2200193   4500008004100000022001400041245011000055210006900165260000900234300001600243490000700259520084100266100002301107700002901130700002101159700002601180700002801206856012101234       2022                        eng d  a0022-326300aLewis acid-catalyzed chemodivergent and regiospecific reaction of phenols with quaternary peroxyoxindoles0 aLewis acidcatalyzed chemodivergent and regiospecific reaction of  cNOV   a14155-141670 v873 a<p>
	The indium-catalyzed regiospecific coupling of substituted phenol derivatives and quaternary peroxyoxindoles for the synthesis of C2 or C4 benzoxazin-3-one-substituted phenols via skeletal rearrangement is described. This reaction is demonstrated with 17 examples with good yields and diverse aryl substituents. In contrast to the indium-catalyzed reaction, the Cu(OTf)2- catalyzed reaction of the phenol with quaternary peroxyoxindoles afforded C2 or C4 2-oxindole-substituted phenol derivatives. This diverse catalytic reaction generated various biologically important phenol-substituted 2-oxindole derivatives directly without any skeleton rearrangement and was demonstrated with 19 examples in high yield. The regiospecificity and the reaction pathways were explained with the support of density functional theory (DFT).</p>
1 aShaikh, Moseen, A.1 aSamal, Pragnya, Paramita1 aUbale, Akash, S.1 aKrishnamurty, Sailaja1 aGnanaprakasam, Boopathy  uhttps://library.ncl.res.in/content/lewis-acid-catalyzed-chemodivergent-and-regiospecific-reaction-phenols-quaternary