01505nas a2200181   4500008004100000022001400041245009600055210006900151260000800220300001400228490000700242520086100249100001801110700002301128700002501151700002401176856012301200       2022                        eng d  a1523-706000aNickel-catalyzed direct synthesis of N-substituted indoles from amino alcohols and alcohols0 aNickelcatalyzed direct synthesis of Nsubstituted indoles from am  cDEC  a9054-90590 v243 a<p>
	A one-pot cascade approach for the synthesis of N substituted indoles from amino alcohols and alcohols under additive and base-free conditions with the liberation of water as the only stoichiometric byproduct is reported. The commercially available bench-stable Ni(OTf)2 salt in combination with 1,2-bis(dicyclohexylphosphino)ethane (dcype) is very effective for this unprecedented catalytic transformation. A broad range of substrates including aromatic and aliphatic primary alcohols, cyclic and acyclic secondary alcohols, and various substituted 2-aminophenyl ethyl alcohols are employed in the reaction conditions to provide a diverse range of N-alkylated indoles. Mechanistic studies revealed that the reaction proceeds through tandem N-alkylation via hydrogen autotransfer followed by the cyclization of N-alkylated alcohol intermediate.</p>
1 aYadav, Vinita1 aJagtap, Sayali, G.1 aBalaraman, Ekambaram1 aMhaske, Santosh, B.  uhttps://library.ncl.res.in/content/nickel-catalyzed-direct-synthesis-n-substituted-indoles-amino-alcohols-and-alcohols