02281nas a2200253   4500008004100000022001400041245012000055210006900175260000800244300001100252490000800263520142300271653001701694653002801711653002601739653001001765653002801775100002001803700001901823700001801842700001801860700001701878856013201895       2023                        eng d  a0021-899500aControlled synthesis of thermosensitive tunable porous film of (pNIPAM)-b-(PCL) copolymer for sustain drug delivery0 aControlled synthesis of thermosensitive tunable porous film of p  cMAY  ae538540 v1403 a<p>
	There have been reports on different types of porous polymer films for various applications. The designing of such porous films with uniform properties is a challenging task. In this work, tunable porous thin films of poly(N-isopropylacrylamide) (pNIPAM) and polycaprolactone (PCL), that is, (pNIPAM)-b-(PCL) has been fabricated and its sustained drug delivery applications have been reported. First, the (pNIPAM)-b-(PCL) has been synthesized through the addition polymerization of pNIPAM and PCL. Then the synthesized (pNIPAM)-b(PCL) has been used to design porous thin film with varying temperatures without using any external template, below and above the lower critical solution temperatures (LCST) of pNIPAM. Pore size in (pNIPAM)-b-(PCL) films has been tuned by varying the temperature from similar to 10 to 40 degrees C. Then the developed thermosensitive porous film has been taken and seeded with the K562 (chronic myeloid leukemia blood cancer) and HepG2 (hepatocarcinoma) cells and the skin cancer cells (B16-F10) killing efficiency of anticancer drug (e.g., doxorubicin hydrochloride, DOX) loaded (pNIPAM)-b-(PCL) film has been studied. It is found that the DOX-loaded (pNIPAM)-b-(PCL) can efficiently kill the skin cancer cells. The porous polymer thin film reported in this work can be a versatile platform for the loading of drugs and it can be used for the various therapeutic applications.</p>
10aBiomaterials10aBiomedical Applications10adrug delivery systems10afilms10ananostructured polymers1 aAmgoth, Chander1 aPatra, Sukanya1 aWasnik, Kirti1 aMaity, Pradip1 aPaik, Pradip  uhttps://library.ncl.res.in/content/controlled-synthesis-thermosensitive-tunable-porous-film-pnipam-b-pcl-copolymer-sustain-drug