02085nas a2200253   4500008004100000022001400041245009600055210006900151260000800220300001400228490000800242520125000250100001801500700001901518700002001537700002001557700002101577700002101598700002101619700002801640700002601668700002201694856011501716       2022                        eng d  a0002-963700aCase report: a fatal case of babesiosis in a splenectomized male patient from Western India0 aCase report a fatal case of babesiosis in a splenectomized male   cMAY  a1421-14250 v1063 a<p>
	Human babesiosis is a rare disease, caused by Babesia species and commonly transmitted by tick bite. Although human babesiosis is known to be asymptomatic in immunocompetent hosts, clinical cases of severe babesiosis have been reported from splenectomized or immunocompromised individuals. To our knowledge, only one case of human babesiosis in India has been previously reported. Here, we report a case of severe babesiosis with high parasitemia (similar to 70%) in a 30-year-old asplenic farmer. The patient presented with fever, yellowish discoloration of skin, oliguria, and anemia; he eventually developed multiorgan failure syndrome and died. Peripheral blood films were prepared and used to confirm the presence of piroplasms by microscopy. Total DNA isolated from blood was used for 18S ribosomal RNA gene fragment amplification by polymerase chain reaction, which was subjected to Sanger sequencing. Although 18S sequence indicated that the Babesia species infecting the patient was similar to that of other Babesia species originating from wild mammals, species identification could not be done. Phylogenetic analysis revealed that the patientderived pathogen is distinct because it forms a separate clade in the cladogram.</p>
1 aGodbole, Ravi1 aGaur, Avantika1 aNayar, Priyanka1 aKiruthiga, Kala1 aD'Costa, Pradeep1 aManchanda, Rumma1 aKhilari, Ajinkya1 aShanmugam, Dhanasekaran1 aMuglikar, Kalpana, D.1 aKundu, Krishnendu  uhttps://library.ncl.res.in/content/case-report-fatal-case-babesiosis-splenectomized-male-patient-western-india