01311nas a2200253 4500008004100000022001400041245011000055210006900165260000800234300001100242490000700253520044700260653001700707653002400724653002200748653002300770100002600793700002000819700002000839700002100859700002400880700002400904856012900928 2022 eng d a0960-894X00aPostmodification of voxelotor (GBT 440) via [Rh]-catalyzed cross dehydrogenative coupling with olefins br0 aPostmodification of voxelotor GBT 440 via Rhcatalyzed cross dehy cDEC a1290220 v773 a

The directed Rh(III)-catalyzed cross dehydrogenative coupling of the pyrazole unit of the GBT-440 scaffold has been explored with simple as well as conjugated olefins to synthesize post-functionalized GBT-440 analogues. The screening of these synthesized compounds for improving the oxygen binding efficiency of the hemoglobin isolated from the sickled red blood cells revealed that some of these compounds are as good as GBT-440.

10aCDC Coupling10aGBT-440 (Voxelotor)10aRh(III) catalysis10asickle cell anemia1 aKalshetti, Rupali, G.1 aRajput, Raveena1 aMotiwala, Zenia1 aReddy, Srinivasa1 aKulkarni, Kiran, A.1 aRamana, Chepuri, V. uhttps://library.ncl.res.in/content/postmodification-voxelotor-gbt-440-rh-catalyzed-cross-dehydrogenative-coupling-olefins-br