01238nas a2200157   4500008004100000022001400041245016900055210006900224260000900293300001400302490000700316520058400323100002100907700002600928856012600954       2022                        eng d  a1477-052000aLewis acid triggered N-alkylation of sulfoximines through nucleophilic ring-opening of donor-acceptor cyclopropanes: synthesis of gamma-sulfoximino malonic diesters0 aLewis acid triggered Nalkylation of sulfoximines through nucleop  cMAR   a2518-25290 v203 a<p>
	Scandium triflate (Sc(OTf)(3)) catalyzed, mild, and regioselective ring-opening reaction of donor-acceptor (D-A) cyclopropanes has been developed using sulfoximines for the synthesis of gamma-sulfoximino malonic diesters. This protocol allows the synthesis of different N-alkyl sulfoximines in good to excellent yields (up to 94%) with broad functional group tolerance. In this process, N-H and C-C bonds are cleaved to form new C-N and C-H bonds. The feasibility of this method is supported by a gram-scale reaction and synthetic elaboration of the obtained product.</p>
1 aMore, Satish, G.1 aSuryavanshi, Gurunath  uhttps://library.ncl.res.in/content/lewis-acid-triggered-n-alkylation-sulfoximines-through-nucleophilic-ring-opening-donor