01581nas a2200169   4500008004100000022001400041245009100055210006900146260000800215300001400223490000600237520100200243100001701245700001701262700002101279856011101300       2022                        eng d  a2058-988300aAssessment of a multipoint dosing approach for exothermic nitration in CSTRs in series0 aAssessment of a multipoint dosing approach for exothermic nitrat  cJUN  a1671-16790 v73 a<p>
	The exothermic aromatic nitration of a biaryl compound is studied using various configurations of CSTRs in series. The relative rates of heat generation and heat removal in different configurations are compared to identify safer options while taking scale-up-related decisions. The effects of different parameters on the steady-state temperatures of the CSTRs are demonstrated through simulations. The use of multipoint dosing in three different CSTRs of increasing volume in series was compared with the use of standard CSTRs of equal volume in series. The distribution of the nitrating agent in three different CSTRs in series helped to distribute the heat duty and thereby helped maximise the throughput almost 2.4-fold when compared with a conventional approach based on the co-addition of all the reactants in the first CSTR. Various feed combinations were studied, and suitable designs that fall within the safe operating range of CSTRs for highly exothermic reactions are given.</p>
1 aMule, G., M.1 aKulkarni, S.1 aKulkarni, A., A.  uhttps://library.ncl.res.in/content/assessment-multipoint-dosing-approach-exothermic-nitration-cstrs-series