01569nas a2200145   4500008004100000245015300041210006900194260000800263300001600271490000700287520095300294100002901247700002201276856012501298       2022                        eng d00aPoly(N-vinylcaprolactam) containing solid lipid polymer hybrid nanoparticles for controlled delivery of a hydrophilic drug gemcitabine hydrochloride0 aPolyNvinylcaprolactam containing solid lipid polymer hybrid nano  cJUN  a17621-176280 v123 a<p>
	Folic acid tagged and hydrophilic polymer containing solid lipid nanoparticles (SLNs) were formulated for the controlled and targeted delivery of gemcitabine, a hydrophilic drug. Drug loaded SLNs were prepared by double emulsion method and optimized by 3(2) level factorial design. Then, a hydrophilic polymer, namely, poly(N-vinylcaprolactam) (PVCL) was incorporated in the optimized SLN batch in the first aqueous phase (W1) to obtain solid lipid polymer hybrid nanoparticles (SLPHNs) that were further decorated with folic acid (F-SLPHNs). TEM analysis of SLNs and SLPHNs revealed the spherical shape with no aggregation while SLPHNs showed higher % EE. SLPHNs exhibited limited burst release of gemcitabine compared to SLNs as well as lower overall % release. All the formulations showed good cytocompatibility against MDA-MB-231 cell lines and folic acid-tagged hybrid particles (F-SLPHNs) showed remarkably higher cellular uptake.</p>
1 aSurapaneni, Sai, Geetika1 aAmbade, Ashootosh  uhttps://library.ncl.res.in/content/polyn-vinylcaprolactam-containing-solid-lipid-polymer-hybrid-nanoparticles-controlled