01643nas a2200169   4500008004100000022001400041245019800055210006900253260000800322300001600330490000700346520091100353100003001264700002601294700002501320856012801345       2022                        eng d  a1144-054600aMetal-free approach towards efficient synthesis of FDCA using a p-toluene sulfonic acid (p-TSA)-derived heterogeneous solid acid catalyst and oxone over two steps from HMF, fructose and glucose0 aMetalfree approach towards efficient synthesis of FDCA using a p  cMAY  a10272-102790 v463 a<p>
	In this work, a metal-free approach towards the synthesis of 2,5-furandicarboxylic acid (FDCA) from 5-hydroxymethylfurfural (HMF), fructose and glucose is reported over two steps using a p-toluene sulfonic acid (p-TSA)-derived heterogeneous solid acid catalyst (p-TSA-POM) in the first step and oxone as an oxidant in the second step. HMF, fructose and glucose were converted to 2,5-diformylfuran (DFF) using the p-TSA-POM catalyst followed by oxidation of DFF to FDCA using oxone. To the best of our knowledge, this is the first metal-free approach for the synthesis of FDCA directly from glucose. DFF was obtained from HMF in 91% yield, whereas it was obtained in 85% and 61% yields from fructose &amp; glucose, respectively. DFF was further converted to FDCA using oxone as an oxidant. FDCA was obtained in an overall yield of 84%, 78% and 56% from HMF, fructose &amp; glucose, respectively.</p>
1 aTamboli, Asma, T. Biradar1 aKirdant, Swapnali, P.1 aJadhav, Vrushali, H.  uhttps://library.ncl.res.in/content/metal-free-approach-towards-efficient-synthesis-fdca-using-p-toluene-sulfonic-acid-p-tsa