01426nas a2200157   4500008004100000022001400041245008400055210006900139260000800208300001400216490000800230520087600238100002101114700002401135856010901159       2022                        eng d  a1520-610600aDry molten globule-like intermediates in protein folding, function, and disease0 aDry molten globulelike intermediates in protein folding function  cNOV  a8614-86220 v1263 a<p>
	The performance of a protein depends on its correct folding to the final functional native form. Hence, understanding the process of protein folding has remained an important field of research for the scientific community for the past five decades. Two important intermediate states, namely, wet molten globule (WMG) and dry molten globule (DMG), have emerged as critical milestones during protein folding-unfolding reactions. While much has been discussed about WMGs as a common unfolding intermediate, the evidence for DMGs has remained elusive owing to their near-native features, which makes them difficult to probe using global structural probes. This Review puts together the available literature and new evidence on DMGs to give a broader perspective on the universality of DMGs and discuss their significance in protein folding, function, and disease.</p>
1 aAcharya, Nirbhik1 aJha, Santosh, Kumar  uhttps://library.ncl.res.in/content/dry-molten-globule-intermediates-protein-folding-function-and-disease