01709nas a2200193   4500008004100000020001400041245014700055210006900202260000800271300001000279490000600289520097400295100002301269700002601292700002501318700001801343700002801361856012601389       2021                        eng d  a2524-793X00aPhysicochemical and in vitro antibacterial evaluation of metronidazole loaded eudragit S-100 nanofibrous mats for the intestinal drug delivery0 aPhysicochemical and in vitro antibacterial evaluation of metroni  cAUG  a76-880 v43 a<p>
	Metronidazole (MTZ) loaded Eudragit S-100 (ES-100) nonwoven nanofibrous mats were successfully electrospun and evaluated for intestinal drug delivery. MTZ was varied in the range of 1–15% (w/w) in ES-100 nanofibrous mats, the morphological characterization of nanofibrous mats was carried out using FE-SEM and the average diameter of nanofiber was found in the range 150–600&nbsp;nm. WAXD and DSC demonstrated the amorphous nature of MTZ in ES-100 nanofibrous mats. Their contact angle analysis confirmed the hydrophobic nature. The mechanical strength of ES-100 nanofibrous mats decreased with increasing MTZ concentration. The drug release profiles showed 74% MTZ release from ES-100d within 2&nbsp;h at pH 6.8 which is the colonic environment. Antibacterial activities against gram-positive bacteria (Staphylococcus aureus) and gram-negative bacteria (Escherichia coli) showed that the ES-100 nanofibrous mats loaded with MTZ exhibited good activity.</p>
1 aRade, Priyanka, P.1 aGiram, Prabhanjan, S.1 aShitole, Ajinkya, A.1 aSharma, Neeti1 aGarnaik, Baijayantimala  uhttps://library.ncl.res.in/content/physicochemical-and-vitro-antibacterial-evaluation-metronidazole-loaded-eudragit-s-100