01406nas a2200217   4500008004100000022001400041245010200055210006900157260000900226300001400235490000700249520064500256100002000901700002300921700002300944700002800967700002100995700001801016700002301034856013101057       2021                        eng d  a1523-706000aStabilization of Azapeptides by N-amide center dot center dot center dot H-N-amide Hydrogen Bonds0 aStabilization of Azapeptides by Namide center dot center dot cen  cJUL   a4949-49540 v233 aAn unusual N-amide center dot center dot center dot H-Namide hydrogen bond (HB) was previously proposed to stabilize the azapeptide beta-turns. Herein we provide experimental evidence for the N-amide center dot center dot center dot H-Namide HB and show that this HB endows a stabilization of 1-3 kcal.mol(-1) and enforces the trans-cis-trans (t-c-t) and cis-cis-trans (c-c-t) amide bond conformations in azapeptides and N-methyl-azapeptides, respectively. Our results indicate that these N-amide center dot center dot center dot H-Namide HBs can have stabilizing contributions even in short azapeptides that cannot fold to form beta-turns.1 aBaruah, Kalpita1 aSahariah, Biswajit1 aSakpal, Sushil, S.1 aDeka, Jugal, Kishore Ra1 aBar, Arun, Kumar1 aBagchi, Sayan1 aSarma, Bani, Kanta  uhttps://library.ncl.res.in/content/stabilization-azapeptides-n-amide-center-dot-center-dot-center-dot-h-n-amide-hydrogen-bonds