02331nas a2200301   4500008004100000022001400041245009800055210006900153260000900222300001000231490000700241520139200248653001701640653001701657653001701674653001401691653001601705653001701721100001501738700002601753700002101779700002701800700001901827700001701846700001801863700001701881856013101898       2022                        eng d  a1751-825300aAlpha Au2S nanoparticles: fungal-mediated synthesis, structural characterization and bioassay0 aAlpha Au2S nanoparticles fungalmediated synthesis structural cha  cJAN   a59-680 v153 aLuminescent nanoparticles synthesized via bio-based protocols that generate nanoparticles having different chemical compositions along with other functionalities (size and morphology) have received huge attention. We have focused our research on gold sulfide nanoparticles (Au2S NPs) and have biosynthesized these NPs using the fungus Humicola sp. The nanoparticles were characterized by Transmission Electron Microscopy, which showed spherical morphology of Au2S. UV-Visible-NIR spectrophotometry, luminescence spectrophotometry, Selected Area Electron Diffraction, Energy Dispersive Analysis of X-rays, and X-ray diffraction were performed. FTIR confirmed that the fungal metabolites including biomolecules secreted in the reaction medium are primarily responsible for nanoparticle synthesis and stabilization. The fungus reduced the precursor solution (HAuCl4 and Na2SO3) and at the same time capped them with secreted biomolecules. The anti-leishmanial activity of Au2S NPs was determined against L. donovani promastigote (Ag83 strain). Au2S NPs displayed less cytotoxicity towards both normal and cancer (Daudi, ZR-75-1) cell lines. Hemocompatibility was determined via hemolysis assays. This novel fungal-based system demonstrates an economical and environmentally benign process for biosynthesis of Au2S nanoparticles which may find application in bioimaging and labeling studies.10aBiosynthesis10aCytotoxicity10aGold sulfide10aHemolysis10ahumicola sp10apromastigote1 aSyed, Asad1 aSaedi, Marzouq, H. Al1 aBahkali, Ali, H.1 aElgorgan, Abdallah, M.1 aKharat, Mahesh1 aPai, Kalpana1 aPichtel, John1 aAhmad, Absar  uhttps://library.ncl.res.in/content/alpha-au2s-nanoparticles-fungal-mediated-synthesis-structural-characterization-and-bioassay