01487nas a2200193   4500008004100000022001400041245009500055210006900150260000800219300001600227490000600243520081100249100002301060700000501083700003101088700002301119700002601142856012501168       2021                        eng d  a2470-134300aNew 1,2,3-triazole-appended bis-pyrazoles: synthesis, bioevaluation, and molecular docking0 aNew 123triazoleappended bispyrazoles synthesis bioevaluation and  cSEP  a24879-248900 v63 aThe present work describes design of a small library of new 1,2,3-triazole-appended bis-pyrazoles by using a molecular hybridization approach, and the synthesized hybrids were evaluated for their antifungal activity against different fungal strains, namely, Candida albicans, Cryptococcus neoformans, Candida glabrata, Candida tropicalis, Aspergillus niger, and Aspergillus fumigatus. All the compounds exhibited broad-spectrum activity against the tested fungal strains with excellent minimum inhibitory concentration values. The molecular docking study against sterol 14 alpha-demethylase (CYP51) could provide valuable insights into the binding modes and affinity of these compounds. Furthermore, these compounds were also evaluated for their antioxidant activity, which also resulted in promising data.1 aDanne, Ashruba, B.1 a1 aSangshetti, Jaiprakash, N.1 aKhedkar, Vijay, M.1 aShingate, Bapurao, B.  uhttps://library.ncl.res.in/content/new-123-triazole-appended-bis-pyrazoles-synthesis-bioevaluation-and-molecular-docking