01896nas a2200193   4500008004100000022001400041245008300055210006900138260000800207300001400215490000700229520124400236100002301480700001901503700002001522700002601542700002101568856011301589       2021                        eng d  a1525-779700aL-Histidine-derived smart antifouling biohybrid with multistimuli responsivity0 aLHistidinederived smart antifouling biohybrid with multistimuli   cSEP  a3941-39490 v223 aA novel dual pH/thermoresponsive amphiphilic poly(histidine methacrylamide)-block-hydroxyl-terminated polybutadiene-block-poly(histidine methacrylamide) (PHisMAM-b-PB-b-PHisMAM) triblock copolymer biohybrid, composed of hydrophobic PB and ampholytic PHisMAM segments, is developed via direct switching from living anionic polymerization to recyclable nanoparticle catalyst-mediated reversible-deactivation radical polymerization (RDRP). The transformation involved in situ postpolymerization modification of living polybutadiene-based carbanionic species, end-capped with ethylene oxide, into dihydroxyl-terminated polybutadiene and a subsequent reaction with 2-bromo-2-methylpropionyl bromide resulting in a telechelic ATRP macroinitiator (Br-PB-Br). Br-PB-Br was used to mediate RDRP of an L-histidine-derived monomer, HisMAM, yielding a series of PHisMAM-b-PB-b-PHisMAM triblock copolymers. The copolymer's stimuli response was assessed against pH and temperature changes. The copolymer is capable of switching among its zwitterionic, anionic, and cationic forms and exhibited unique antifouling properties in its zwitterionic form. These novel triblock copolymers are expected to be show promising potential in biomedical applications.1 aMohammad, Sk, Arif1 aDolui, Subrata1 aKumar, Devendra1 aMane, Shivshankar, R.1 aBanerjee, Sanjib  uhttps://library.ncl.res.in/content/l-histidine-derived-smart-antifouling-biohybrid-multistimuli-responsivity