01574nas a2200145   4500008004100000022001400041245009000055210006900145260000900214300001600223490000800239520105900247100001501306856010701321       2021                        eng d  a1520-610600aSystematic search for a predictor for the clinical observables of alzheimer's disease0 aSystematic search for a predictor for the clinical observables o  cNOV   a12177-121860 v1253 aOne of the prevailing life-threatening incurable neurodegenerative diseases that are presently endangering human society as a whole, and hence, baffling the entire spectrum of the scientific and pharmaceutical world, is Alzheimer's disease (AD). AD is a manifestation of self-assembly of both wild-type (sporadic) and mutated (familial) forms of the amyloid-beta peptide, a proteolytic product of the amyloid precursor protein, where the self-assembly results in the genesis of pathogenic fibrillar aggregates. Currently prevailing diagnostic and hence therapeutic challenges originate from the unavailability of a specific predictor for clinical observables. The continuous emergence of novel pathogenic mutants with unpredictable phenotypes adds immensely to the nonspecific nature of the problem. The current research reports a simple physical parameter, the binding affinity of a protofilament to its protofibril, which predicts the clinical observables of familial AD with astounding accuracy and more importantly, without any adjustable parameters.1 aDas, Atanu  uhttps://library.ncl.res.in/content/systematic-search-predictor-clinical-observables-alzheimers-disease