02158nas a2200157   4500008004100000022001400041245011300055210006900168260000900237300001400246490000700260520156200267100001701829700002401846856013001870       2021                        eng d  a1477-052000aC (1)-Symmetric diphosphorus ligands in metal-catalyzed asymmetric hydrogenation to prepare chiral compounds0 aC 1Symmetric diphosphorus ligands in metalcatalyzed asymmetric h  cNOV   a9095-91370 v193 aAsymmetric hydrogenation has remained an important and challenging research area in industry as well as academia due to its high atom economy and ability to induce chirality. Among several types of ligands, chiral bidentate phosphine ligands have played a pivotal role in developing asymmetric hydrogenation. Although C-2-symmetric chiral bidentate phosphine ligands have dominated the field, it has been found that several C-1-symmetric ligands are equally effective and, in many cases, have outperformed their C-2-symmetric counterparts. This review evaluates the possibility of the use of C-1-symmetric diphosphorus ligands in asymmetric hydrogenation to produce chiral compounds. The recent strategies and advances in the application of C-1-symmetric diphosphorus ligands in the metal-catalyzed asymmetric hydrogenation of a variety of C=C bonds have been summarized. The potential of diphosphorus ligands in asymmetric hydrogenation to produce pharmaceutical intermediates, bioactive molecules, drug molecules, agrochemicals, and fragrances is discussed. Although asymmetric hydrogenation appears to be a problem that has been resolved, a deep dive into the recent literature reveals that there are several challenges that are yet to be addressed. The current asymmetric hydrogenation methods mostly employ precious metals, which are depleting at a fast pace. Therefore, scientific interventions to perform asymmetric hydrogenation using base metals or earth-abundant metals that can compete with established precious metals hold significant potential.1 aSen, Anirban1 aChikkali, Samir, H.  uhttps://library.ncl.res.in/content/c-1-symmetric-diphosphorus-ligands-metal-catalyzed-asymmetric-hydrogenation-prepare-chiral