01399nas a2200193   4500008004100000022001400041245015900055210006900214260000900283300001400292490000700306520066400313100001800977700001600995700001801011700002401029700002201053856013001075       2021                        eng d  a1523-706000aEnantioselective synthesis of 5,6-dihydroindolizines by N-heterocyclic carbene (NHC)-catalyzed core-structure-inspired strategy of azolium-enolate cascade0 aEnantioselective synthesis of 56dihydroindolizines by Nheterocyc  cJUL   a5223-52280 v233 aThe core-structure motivated design has allowed the enantioselective synthesis of 5,6-dihydroindolizines via N-heterocyclic carbene (NHC) catalysis. The NHC-catalyzed reaction of alpha,beta-unsaturated aldehydes with the suitably substituted pyrrole derivatives proceed via the initial generation of alpha,beta-unsaturated acylazoliums from enals, and enolates from pyrroles and the reaction culminated in an efficient cascade process involving the Michael-aldol-lactonization-decarboxylation sequence to afford the products in reasonable yields and high selectivities. The method is further extended to the construction of spirocyclic 5,6-dihydroindolizines.1 aGhosh, Arghya1 aShee, Sayan1 aBarik, Shilpa1 aGonnade, Rajesh, G.1 aBiju, Akkattu, T.  uhttps://library.ncl.res.in/content/enantioselective-synthesis-56-dihydroindolizines-n-heterocyclic-carbene-nhc-catalyzed-core