01605nas a2200241   4500008004100000022001400041245010400055210006900159260000900228300001600237490000700253520076200260653002001022653003201042653001601074653002401090653002701114100002201141700002601163700002401189700002301213856012701236       2021                        eng d  a0947-653900aMulti-step synthesis of miltefosine: integration of flow chemistry with continuous mechanochemistry0 aMultistep synthesis of miltefosine integration of flow chemistry  cDEC   a17695-176990 v273 aHerein we report for the first time, an advanced continuous flow synthesis of the blockbuster Leishmaniasis drug miltefosine from simple starting materials by a sequence involving four steps of chemical transformation including a continuous mechanochemical step. First three reaction steps were performed in simple tubular reactors in a telescopic mode, while in the last step the product precipitated from the 3(rd) step was used for a continuous mechanochemical synthesis of miltefosine. When compared to a typical batch protocol that takes 15 h, miltefosine was obtained in 58 % overall yield in flow synthesis mode at the laboratory scale in a total residence time 34 min at synthesis rate of 10 g/hr, which is sufficient to treat 4800 patients per day.10acontinuous flow10acontinuous mechanochemistry10amiltefosine10amultistep synthesis10areactive intermediates1 aPatil, Niteen, B.1 aAtapalkar, Ranjit, S.1 aChavan, Subhash, P.1 aKulkarni, Amol, A.  uhttps://library.ncl.res.in/content/multi-step-synthesis-miltefosine-integration-flow-chemistry-continuous-mechanochemistry