01345nas a2200157   4500008004100000022001400041245010400055210006900159260000900228300001400237490000700251520076000258100002601018700002001044856012301064       2021                        eng d  a0022-326300aPd(II)-catalyzed chemoselective acetoxylation of C(sp(2))-H and C(sp(3))-H bonds in tertiary amides0 aPdIIcatalyzed chemoselective acetoxylation of Csp2H and Csp3H bo  cJUN   a8172-81810 v863 aPalladium-catalyzed chemoselective C(sp(2))-H and C(sp(3))-H acetoxylation of synthetically useful tertiary amides is reported under relatively mild reaction conditions. This protocol proceeds through the assistance of a weakly coordinated directing group (C = O) and requires low catalyst (1.0 mol %) loading. Diverse functionalities, such as C(sp(2))-Cl, C(sp(3))-Cl, -CF3, -COOEt, and -NO2 groups, including morpholinyl, piperazinyl, and pyrrolidinyl heterocycles, are compatible under the reaction conditions. Further functionalization of this protocol is demonstrated by hydrolysis to alcohols, alcohol-acids, as well as reduction to tertiary amines. A preliminary kinetic isotope effect study supported the rate-limiting C-H bond activation process.1 aVijaykumar, Muniyappa1 aPunji, Benudhar  uhttps://library.ncl.res.in/content/pdii-catalyzed-chemoselective-acetoxylation-csp2-h-and-csp3-h-bonds-tertiary-amides