01764nas a2200253   4500008004100000022001400041245012200055210006900177260000800246300000800254490000700262520090100269653002201170653001501192653003801207653001301245653002201258100001801280700002201298700002301320700001801343700002501361856012401386       2021                        eng d  a1022-976000aConstruction of beta-cyclodextrin linked glycidyl methacrylate polymers for stereoselective separation of chiral drug0 aConstruction of betacyclodextrin linked glycidyl methacrylate po  cAUG  a2870 v283 aIn this present study, a series of cross-linked porous polymers based on Glycidyl Methacrylate (GMA) were synthesized by suspension polymerization using cyclohexanol and hexanol as pore generating solvents. beta-cyclodextrin (beta-CD) was covalently bonded to the polymers by using Hexamethylene Diisocyanate (HMDI) and Sebacoyl Chloride (SC) as spacer arms. The effects of matrix properties such as pore volume, type of crosslinker, and spacer on the loading of beta-cyclodextrin were investigated. The stereoselective binding of enantiomers of the anti-depressant drug citalopram was studied using beta-cyclodextrin loaded polymers under batch adsorption mode. The capacity factor and selectivity of isomers were investigated also. This study reveals that these beta-cyclodextrin bonded Glycidyl Methacrylate (GMA) polymers are potentially suitable for chromatographic separation of citalopram.10abeta-cyclodextrin10aCitalopram10aGlycidyl Methacrylate (GMA) beads10aHPLC etc10aStereoslelctivity1 aWale, Apparav1 aMulani, Khudbudin1 aDeshpande, Supriya1 aRajan, C., R.1 aPonrathnam, Surendra  uhttps://library.ncl.res.in/content/construction-beta-cyclodextrin-linked-glycidyl-methacrylate-polymers-stereoselective