00991nas a2200217 4500008004100000022001400041245006200055210005800117260000800175300001100183490000700194520034300201653002300544653001800567653001400585653001500599100002100614700002200635700002600657856009000683 2021 eng d a0040-403900aShort enantioselective total synthesis of (+)-tofacitinib0 aShort enantioselective total synthesis of tofacitinib cMAR a1528380 v673 a

An enantioselective total synthesis of Tofacitinib (CP-690,550), a Janus tyrosine kinase (JAK3) specific inhibitor has been achieved from the readily available 4-piperidone. Proline catalysed hydroxylation is the key step for the synthesis of enantiopure 1-benzyl-4-methylpiperidin-3-ol. (C) 2021 Elsevier Ltd. All rights reserved.

10aaminohydroxylation10aHydrogenation10aL-proline10apiperidone1 aMane, Kishor, D.1 aKamble, Rohit, B.1 aSuryavanshi, Gurunath uhttps://library.ncl.res.in/content/short-enantioselective-total-synthesis-tofacitinib