01853nas a2200217   4500008004100000022001400041245006600055210006400121260000900185300001600194490000600210520113100216100002101347700002101368700002201389700002501411700003501436700002701471700003601498856010101534       2021                        eng d  a2470-134300aAmyloid-beta-derived peptidomimetics inhibits tau aggregation0 aAmyloidbetaderived peptidomimetics inhibits tau aggregation  cMAY   a11131-111380 v63 a<p>The aggregation of tau protein is one of the hallmarks for Alzheimer's disease, resulting in neurodegeneration. The peptidomimetics strategy to prevent tau aggregation is more specific over other small molecules. In the present study, we analyzed the effect of amyloid-beta-derived peptidomimetics for inhibiting heparin-induced tau aggregation in vitro. These peptides and their derivatives were known to prevent aggregation of amyloid-beta. KLVFF is a hydrophobic sequence of the pentapeptide that prevented tau aggregation as observed by thioflavin S fluorescence, transmission electron microscopy, and circular dichroism spectroscopy. P4 and P5 also prevented assembly of tau into aggregates and formed short fibrils. The beta-sheet breaker LPFFD was however ineffective in preventing tau aggregation. The peptides further demonstrated reversal of tau-induced cytotoxicity in a dose-dependent manner. Our results suggested that these peptides can also be used to inhibit tau aggregation and also, toxicity induced by tau could be considered as potential molecules that have an effect on tau as well as amyloid-beta.</p>1 aGorantla, Nalini1 aSunny, Lisni, P.1 aRajasekhar, Kolla1 aNagaraju, Pramod, G.1 aPriyadarshini, Poornima, C. G.1 aGovindaraju, Thimmaiah1 aChinnathambi, Subashchandrabose  uhttps://library.ncl.res.in/content/amyloid-beta-derived-peptidomimetics-inhibits-tau-aggregation