01576nas a2200157   4500008004100000022001400041245012400055210006900179260000800248300001400256490000600270520096900276100002201245700002201267856012901289       2021                        eng d  a2052-412900aStrategies for the synthesis of furo-pyranones and their application in the total synthesis of related natural products0 aStrategies for the synthesis of furopyranones and their applicat  cMAY  a2110-21620 v83 a<p>The furo-pyranone framework is widely present in the molecular structure of various biologically potent natural products and un-natural small molecules, and it represents a valuable target in synthetic organic chemistry and medicinal chemistry. In the last five decades, numerous innovative synthetic methodologies have been disclosed for these bis-oxacyclic fused heterocycles, expanding the scope of accessible building blocks, efficient and affordable catalysis, facile reaction conditions, and overall practicality of the process. In this comprehensive review article, we focus on showcasing the complete spectrum (from the first report in the 1970s to the latest disclosure in 2020) of efforts devoted towards the synthesis of diverse classes of furo-pyranones through systematization and critical analysis of the accumulated experimental knowledge and their elegant applications in total syntheses of biologically interesting related natural products.</p>1 aThorat, Sagar, S.1 aKontham, Ravindar  uhttps://library.ncl.res.in/content/strategies-synthesis-furo-pyranones-and-their-application-total-synthesis-related-natural