01364nas a2200145   4500008004100000245008900041210006900130260000800199490000700207520082400214100002001038700002001058700002001078856012001098       2019                        eng d00aActin cytoskeleton and membrane interactions: role in GPCR function and organization0 aActin cytoskeleton and membrane interactions role in GPCR functi  cSEP0 v853 a<p>Cell signaling networks are generally initiated at the cell membrane and mediated by receptors such as the G proteincoupled receptors (GPCRs). Adjacent to the cell membrane lies a complex network of proteins - the actin cytoskeleton to which several structural and physiological roles have been attributed. An emerging role of the cytoskeleton is to modulate GPCR function and organization, either directly or indirectly. The GPCR-cytoskeleton cross-talk is a complex hierarchical process where each step has its own set of rules and combinations. Due to the inherent complexity involved at each step and the multiple spatio-temporal levels, a complete picture is yet to emerge. In this review article, we provide an overview of actin-membrane interactions and how they modulate GPCR function and organization.</p>
1 aPrakash, Shikha1 aKrishna, Anjali1 aSengupta, Durba  uhttps://library.ncl.res.in/content/actin-cytoskeleton-and-membrane-interactions-role-gpcr-function-and-organization