01798nas a2200229   4500008004100000022001400041245011900055210006900174260000800243300001200251490000700263520100700270653004101277653001601318653001401334653002001348653001501368100001501383700002001398700002301418856012701441       2021                        eng d  a2062-249X00aAntisolvent based ultrasound-assisted batch and continuous flow precipitation of metformin hydrochloride particles0 aAntisolvent based ultrasoundassisted batch and continuous flow p  cJUN  a181-1920 v113 a<p>Small sized particles of the antidiabetic drug metformin hydrochloride (MET.HCl) were produced by antisolvent based precipitation using an ultrasound assisted inverted jet reactor (IJR). This novel approach was implemented as a small passive mixer in which intensified turbulent mixing of the solution and the antisolvent occurred under controlled conditions. The optimized conditions for antisolvent precipitation (ASP) were investigated by studying the effect of solute concentration, antisolvent to solvent ratio and antisolvent temperature in batch systems. The optimized batch precipitation conditions were successfully translated into continuous flow process for the ultrasound assisted inverted jet reactor. The ability of the proposed clogging free inverted jet reactor approach can provide a scaled up alternative pathway to micro and millifluidic devices for manufacturing of small sized API particles, such as, MET.HCl for the formulations and encapsulations on an industrial scale.</p>
10aContinuous antisolvent precipitation10aJet-reactor10aMetformin10asupersaturation10aUltrasound1 aPal, Sayan1 aNikam, Arun, V.1 aKulkarni, Amol, A.  uhttps://library.ncl.res.in/content/antisolvent-based-ultrasound-assisted-batch-and-continuous-flow-precipitation-metformin