02005nas a2200217   4500008004100000022001400041245006700055210006600122260000800188300001400196490000800210520130300218653002401521653002001545653002701565653003401592100001901626700002301645700002201668856009701690       2021                        eng d  a0273-228900aCold active lipases: biocatalytic tools for greener technology0 aCold active lipases biocatalytic tools for greener technology  cJUL  a2245-22660 v1933 a<p>Lipases are enzymes that catalyze the ester bond hydrolysis in triglycerides with the release of fatty acids, mono- and diglycerides, and glycerol. The microbial lipases account for \$400 million market size in 2017 and it is expected to reach \$590 million by 2023. Many biotechnological processes are expedited at high temperatures and hence much research is dealt with thermostable enzymes. Cold active lipases are now gaining importance in the detergent, synthesis of chiral intermediates and frail/fragile compounds, and food and pharmaceutical industries. In addition, they consume less energy since they are active at low temperatures. These cold active lipases have not been commercially exploited so far compared to mesophilic and thermophilc lipases. Cold active lipases are distributed in microbes found at low temperatures. Only a few microbes were studied for the production of these enzymes. These cold-adapted enzymes show increased flexibility of their structures in response to freezing effect of the cold habitats. This review presents an update on cold-active lipases from microbial sources along with some structural features justifying high enzyme activity at low temperature. In addition, recent achievements on their use in various industries will also be discussed.</p>
10aCold active lipases10aFrail compounds10aPsychrophilic microbes10aSynthesis of chiral molecules1 aMhetras, Nutan1 aMapare, Vidhyashri1 aGokhale, Digambar  uhttps://library.ncl.res.in/content/cold-active-lipases-biocatalytic-tools-greener-technology