02459nas a2200253   4500008004100000022001400041245008600055210006900141260000800210300000900218490000700227520166700234653001501901653001301916653002101929653001901950653001601969100002401985700002502009700002202034700002402056700001602080856010902096       2020                        eng d  a1663-981200aPhytochemicals in cancer treatment: from preclinical studies to clinical practice0 aPhytochemicals in cancer treatment from preclinical studies to c  cJAN  a16140 v103 a<p>Cancer is a severe health problem that continues to be a leading cause of death worldwide. Increasing knowledge of the molecular mechanisms underlying cancer progression has led to the development of a vast number of anticancer drugs. However, the use of chemically synthesized drugs has not significantly improved the overall survival rate over the past few decades. As a result, new strategies and novel chemoprevention agents are needed to complement current cancer therapies to improve efficiency. Naturally occurring compounds from plants known as phytochemicals, serve as vital resources for novel drugs and are also sources for cancer therapy. Some typical examples include taxol analogs, vinca alkaloids such as vincristine, vinblastine, and podophyllotoxin analogs. These phytochemicals often act via regulating molecular pathways which are implicated in growth and progression of cancer. The specific mechanisms include increasing antioxidant status, carcinogen inactivation, inhibiting proliferation, induction of cell cycle arrest and apoptosis; and regulation of the immune system. The primary objective of this review is to describe what we know to date of the active compounds in the natural products, along with their pharmacologic action and molecular or specific targets. Recent trends and gaps in phytochemical based anticancer drug discovery are also explored. The authors wish to expand the phytochemical research area not only for their scientific soundness but also for their potential druggability. Hence, the emphasis is given to information about anticancer phytochemicals which are evaluated at preclinical and clinical level.</p>
10aAnticancer10aclinical10amedicinal plants10aphytochemicals10apreclinical1 aChoudhari, Amit, S.1 aMandave, Pallavi, C.1 aDeshpande, Manasi1 aRanjekar, Prabhakar1 aPrakash, Om  uhttps://library.ncl.res.in/content/phytochemicals-cancer-treatment-preclinical-studies-clinical-practice