01818nas a2200157   4500008004100000022001400041245013700055210006900192260000900261300001400270490000700284520120200291100002401493700001701517856012601534       2020                        eng d  a0003-270000aEnantioselective separation using chiral amino acid functionalized polyfluorene coated on mesoporous anodic aluminum oxide membranes0 aEnantioselective separation using chiral amino acid functionaliz  cMAY   a6850-68570 v923 a<p>Homochiral mesoporous anodic aluminum oxide membranes (AAO) were prepared by coating protected chiral D/L aspartic acid appended polyfluorene in the pores. These chiral AAO membranes successfully demonstrated enantioselective recognition and separation of a range of amino acids from their aqueous racemic mixture by simple filtration. Enantioselective separation was achieved by selective adsorption of one enantiomer from the aqueous racemic mixture into the chiral pores of the AAO membrane leaving the filtrate enriched with the other enantiomer. Extraction and quantification of the adsorbed amino acid (glutamic acid) demonstrated that 1 mg of homochiral polyfluorene could effectively extract about 3.5 mg of glutamic acid with 95% enantiomeric excess in 24 h. This is one of the highest enantiomeric excesses (ee %) and yields reported so far in the literature for a racemic mixture of glutamic acid. The pore size of the AAO membrane influenced the efficiency of separation with a reduction in pore size from 200 to 20 nm leading to reduced ee % (similar to 95% to similar to 28%). These results raise the possibility for a facile method to carry out enantioselective separation.</p>
1 aNikam, Shrikant, B.1 aAsha, S., K.  uhttps://library.ncl.res.in/content/enantioselective-separation-using-chiral-amino-acid-functionalized-polyfluorene-coated