01835nas a2200157   4500008004100000022001400041245015800055210006900213260000800282300001300290490000700303520119500310100001901505700002101524856013201545       2020                        eng d  a1932-620300aDifferential suitability of reactive oxygen species and the role of glutathione in regulating paradoxical behavior in gliomas: a mathematical perspective0 aDifferential suitability of reactive oxygen species and the role  cJUN  ae02352040 v153 a<p>Manipulative strategies of ROS in cancer are often exhibited as changes in the redox and thiol ratio of the cells. Cellular responses to oxidative insults are generated in response to these changes which are triggered due to the rerouting of the metabolic framework to maintain survival under stress. However, mechanisms of these metabolic re-routing are not clearly understood and remained debatable. In the present work, we have designed a context-based dynamic metabolic model to establish that the coordinated functioning of glutathione peroxidase (GTHP), glutathione oxidoreductase (GTHO) and NADPH oxidase (NOX) is crucial in determining cancerous transformation, specifically in gliomas. Further, we propose that the puzzling duality of ROS (represented by changes inh(2)o(2)in the present model) in exhibiting varying cellular fates can be determined by considering simultaneous changes innadph/nadp(+)andgsh/gssgthat occur during the reprogramming of metabolic reactions. This will be helpful in determining the pro-apoptotic or anti-apoptotic fate of gliomas and can be useful in designing effective pro-oxidant and/or anti-oxidant therapeutic approaches against gliomas.</p>
1 aBhowmick, Rupa1 aSarkar, Ram, Rup  uhttps://library.ncl.res.in/content/differential-suitability-reactive-oxygen-species-and-role-glutathione-regulating-paradoxical