01473nas a2200157   4500008004100000022001400041245008300055210006900138260000900207300001400216490000700230520092400237100002201161700002201183856011001205       2020                        eng d  a1359-734500aImines as acceptors and donors in N-heterocyclic carbene (NHC) organocatalysis0 aImines as acceptors and donors in Nheterocyclic carbene NHC orga  cAUG   a8537-85520 v563 a<p>The synthetic potential of imines as electrophiles or as a source of nucleophilic coupling partner in N-heterocyclic carbene (NHC) catalysis for the synthesis of various nitrogen heterocycles and functionalized amines is highlighted in this Feature Article. Electrophilic imines are suitable candidates for intercepting the NHC-derived acyl anions, homoenolate equivalents, and (di)enolates for the synthesis of alpha-amino ketones and a variety of lactam derivatives. Moreover, enamines generated from imines bearing alpha-hydrogen could be trapped with alpha,beta-unsaturated acylazoliums for the synthesis of functionalized dihydropyridinones. NHCs are also useful for the umpolung of imines for the generation of aza-Breslow intermediates thus leading to the synthesis of indoles, quinolines, dihydroquinoxalinesetc.A concise account of the diverse reactivity of imines in NHC catalysis has been presented.</p>
1 aDas, Tamal, Kanti1 aBiju, Akkattu, T.  uhttps://library.ncl.res.in/content/imines-acceptors-and-donors-n-heterocyclic-carbene-nhc-organocatalysis