01673nas a2200181   4500008004100000022001400041245006700055210006500122260000900187300001600196490000700212520109500219100002201314700002001336700002101356700002101377856009301398       2020                        eng d  a0022-262300aTeixobactin: a paving stone toward a new class of antibiotics?0 aTeixobactin a paving stone toward a new class of antibiotics  cNOV   a12171-121950 v633 a<p>Antimicrobial resistance is a serious threat to human health worldwide, prompting research efforts on a massive scale in search of novel antibiotics to fill an urgent need for a remedy. Teixobactin, a macrocyclic depsipeptide natural product, isolated from uncultured bacteria (Elef theria terrae), displayed potent activity against several Gram-positive pathogenic bacteria. The distinct pharmacological profile and interesting structural features of teixobactin with nonstandard amino acid (three Damino acids and L-allo-enduracididine) residues attracted several research groups to work on this target molecule in search of novel antibiotics with new mechanism. Herein, we present a comprehensive and critical perspective on immense possibilities offered by teixobactin in the domain of drug discovery. Efforts made by various research groups since its isolation are discussed, highlighting the molecule's considerable potential with special emphasis on replacement of amino acids. Critical analysis of synthetic efforts, SAR studies, and the way forward are provided hereunder.</p>
1 aGunjal, Vidya, B.1 aThakare, Ritesh1 aChopra, Sidharth1 aReddy, Srinivasa  uhttps://library.ncl.res.in/content/teixobactin-paving-stone-toward-new-class-antibiotics