01433nas a2200181 4500008004100000022001400041245007000055210006800125260000800193520083500201653002401036653002601060653001101086653001301097100002201110700002001132856009901152 2019 eng d a2193-580700aC-H functionalization of indoles by 3d transition-metal catalysis0 aCH functionalization of indoles by 3d transitionmetal catalysis cDEC3 a

Over the past decade, the use of 3d transition metal for the regioselective C-H bond functionalization of indoles has significantly increased. Particularly, advances in manganese, iron, cobalt, nickel and copper catalysis have demonstrated the selective C(2)-H and C(3)-H arylation, alkenylation, alkynylation and alkylation to a greater extent. Similarly, the C-O and C-N bond-forming reactions are manifested via direct C-H bond activation by these earth-abundant metals. The emergence of 3d metals in selective functionalization of the biologically relevant indoles and related heteroarenes would make this protocol more attractive for practical applications. Herein, we provide a brief overview of 3d transition metal-catalyzed (mostly Mn, Fe, Co, Ni and Cu) C-H functionalization of indoles and related heteroarenes.

10a3d transition metal10aC-H functionalization10aIndole10aindoline1 aJagtap, Rahul, A.1 aPunji, Benudhar uhttps://library.ncl.res.in/content/c-h-functionalization-indoles-3d-transition-metal-catalysis