01258nas a2200169   4500008004100000022001400041245009100055210006900146260000800215300001600223490000700239520065800246100002200904700002600926700002000952856011600972       2019                        eng d  a0022-326300aNickel-catalyzed C(2)-H arylation of indoles with aryl chlorides under neat conditions0 aNickelcatalyzed C2H arylation of indoles with aryl chlorides und  cOCT  a12800-128080 v843 a<p>Nickel-catalyzed regioselective C(2)-H arylation of indoles and pyrroles with aryl chlorides is achieved under neat conditions. This method allows the efficient coupling of diverse aryl chlorides employing a user-friendly and inexpensive Ni(OAc)(2)/dppf catalyst system at 80 degrees C. Numerous functionalities, such as halides, alkyl ether, fluoro-alkyl ether, and thioether, and substituted amines, including heteroarenes like benzothiazolyl, pyrrolyl, indolyl, and carbazolyl, are well tolerated under the reaction conditions. The preliminary mechanistic study highlights a single-electron transfer (SET) pathway for the arylation reaction.</p>
1 aPandey, Dilip, K.1 aVijaykumar, Muniyappa1 aPunji, Benudhar  uhttps://library.ncl.res.in/content/nickel-catalyzed-c2-h-arylation-indoles-aryl-chlorides-under-neat-conditions