01113nas a2200193 4500008004100000022001400041245012400055210006900179260000800248300001400256490000700270520042200277100001700699700002000716700001800736700001700754700002000771856012800791 2019 eng d a1477-052000aDiastereoselective multi-component tandem condensation: synthesis of 2-amino-4-(2-furanone)-4H-chromene-3-carbonitriles0 aDiastereoselective multicomponent tandem condensation synthesis  cOCT a8853-88570 v173 a

A general strategy for a one-pot stereoselective synthesis of 2-amino-4-(2-furanone)-4H-chromene-3-carbonitriles by reaction of salicylaldehyde, malononitrile and butenolides via a tandem Knoevenagel/Pinner/vinylogous Michael condensation is presented. The beta,gamma-butenolides gave a syn-selective MCR adduct with a dr up to 11.5 : 1. The mechanistic insight into the MCR was obtained by DFT calculations.

1 aGupta, Vijay1 aSahu, Debashish1 aJain, Shailja1 aVanka, Kumar1 aSingh, Ravi, P. uhttps://library.ncl.res.in/content/diastereoselective-multi-component-tandem-condensation-synthesis-2-amino-4-2-furanone-4h