01399nas a2200169   4500008004100000022001400041245011100055210006900166260000900235300001400244490000700258520076400265100002401029700002601053700002301079856012701102       2019                        eng d  a1463-926200aContinuous flow solvent free organic synthesis involving solids (reactants/products) using a screw reactor0 aContinuous flow solvent free organic synthesis involving solids   cOCT   a5639-56460 v213 a<p>Here we report for the first-time various organic transformations such as aldol condensation, oxidation, nucleophilic substitutions, protection, acylations and coupling reactions using a mechanochemical approach at a controlled temperature using a single synthesis platform. Almost minimal solvents or solvent-free conditions are used, making it a very efficient and clean synthesis of various products. A jacketed screw reactor when operated at different temperatures (0 degrees C to 160 degrees C) and over a range of rotation speeds for changing the residence time (15 s-300 s) helped to achieve maximum conversion. This approach is also extended to the synthesis using substrates having different substitutions, heterocycles and steric hindrance.</p>
1 aSharma, Brijesh, M.1 aAtapalkar, Ranjit, S.1 aKulkarni, Amol, A.  uhttps://library.ncl.res.in/content/continuous-flow-solvent-free-organic-synthesis-involving-solids-reactantsproducts-using