00930nas a2200181 4500008004100000022001400041245006600055210006600121260000900187300001600196490000700212520034100219100002500560700002200585700002100607700002200628856009800650 2019 eng d a1144-054600aNew enantioselective synthesis of antiobesity drug lorcaserin0 aNew enantioselective synthesis of antiobesity drug lorcaserin cNOV  a16876-168800 v433 a

A simple and efficient enantioselective synthesis of anti-obesity drug lorcaerin starting from easily accessible 3-chlorostyrene oxide has been described for the first time employing hydrolytic kinetic resolution as a source of chirality. The protocol might also be useful in the synthesis of structural variants of lorcaserin.

1 aGhotekar, Ganesh, S.1 aMore, Devidas, A.1 aNalla, Viswanadh1 aMuthukrishnan, M. uhttps://library.ncl.res.in/content/new-enantioselective-synthesis-antiobesity-drug-lorcaserin