01242nas a2200157   4500008004100000245009200041210006900133260000800202300001400210490000700224520066300231100002800894700002500922700002100947856011600968       2019                        eng d00aRoute to access imidazol[1,5-a]indole-1,3-diones and pyrrolo[1,2-c]imidazole-1,3-diones0 aRoute to access imidazol15aindole13diones and pyrrolo12cimidazol  cSEP  a8384-83900 v173 a<p>A novel and practical route to synthesize imidazol[1,5-a]indoles and pyrrolo[1,2-c]imidazoles via N-H functionalization has been developed. Indole-2-carboxylic acid or pyrrole-2-carboxylic acid with diverse aniline groups and carbonyldiimidazole (CDI), in the presence of a base under microwave conditions, resulted in imidazol[1,5-a]indoles and pyrrolo[1,2-c]imidazoles, respectively. The present method is free of work-up and no need for column chromatography. Both title scaffolds can serve as useful heterocyclic scaffolds in medicinal chemistry as such, or they can be used as building blocks to construct different classes of useful compounds.</p>
1 aRao, Ramana, Sreenivasa1 aShajan, Fere, Joseph1 aReddy, Srinivasa  uhttps://library.ncl.res.in/content/route-access-imidazol15-aindole-13-diones-and-pyrrolo12-cimidazole-13-diones