01876nas a2200145 4500008004100000245014500041210006900186260000800255520126300263100002401526700001801550700001701568700002101585856012401606 2019 eng d00aSynthesis of chiral tetrahydrofuran building blocks from pantolactones: application in the synthesis of empagliflozin and amprenavir analogs0 aSynthesis of chiral tetrahydrofuran building blocks from pantola cJUL3 a

Chiral 4,4-dimethyl tetrahydrofuran (THF) derivatives were synthesized from commercially available D-(-)/ l-(+) pantolactones, which can serve as chiral building blocks in medicinal chemistry. In addition, two of the synthesized building blocks were utilized for the synthesis of new amprenavir (HIV protease inhibitor) and empagliflozin (anti-diabetic) analogs. The synthesized analogs may have beneficial effects in terms of pharmacokinetics and modulation of bioactivity.

1 aAthawale, Paresh, R1 aKumari, Neeta1 aKashinath, K1 aReddy, Srinivasa uhttps://library.ncl.res.in/content/synthesis-chiral-tetrahydrofuran-building-blocks-pantolactones-application-synthesis