01227nas a2200157   4500008004100000022001400041245014100055210006900196260000900265300001400274490000700288520059200295100002700887700002400914856013100938       2019                        eng d  a0022-326300aRu-catalyzed regioselective cascade annulation of acrylamides with 2-alkynoates for the synthesis of various 6-Oxo nicotinic acid esters0 aRucatalyzed regioselective cascade annulation of acrylamides wit  cFEB   a1863-18700 v843 a<p>Ru-catalyzed regioselective cascade annulation of acrylamides with 2-alkynoates via aza-Michael/C-H activation sequence for the synthesis of various 6-oxo nicotinic acid esters is described. The regioselectivity of the protocol has been confirmed by performing silver mediated protodecarboxylation of the corresponding 6-oxo nicotinic acid to furnish 2-pyridone. The developed protocol is copper or silver salt-free and uses inexpensive, safe, and environmentally benign peroxide-based ``oxone'' as the sole oxidant. A redox-neutral version of the protocol is also demonstrated.</p>
1 aGarad, Dnyaneshwar, N.1 aMhaske, Santosh, B.  uhttps://library.ncl.res.in/content/ru-catalyzed-regioselective-cascade-annulation-acrylamides-2-alkynoates-synthesis-various-6