01359nas a2200181   4500008004100000022001400041245016700055210006900222260000900291300001400300490000700314520063400321100002600955700001900981700002401000700002201024856013101046       2019                        eng d  a1523-706000aFe(III)-Catalyzed diastereoselective friedel-crafts alkylation-hemiketalization-lactonization cascade for the synthesis of polycyclic bridged 2-chromanol lactones0 aFeIIICatalyzed diastereoselective friedelcrafts alkylationhemike  cAPR   a2629-26330 v213 a<p>An unprecedented Fe(III)-catalyzed Friedel-rafts alkylation-hemiketalization-lactonization cascade of electron-rich hydroxy arenes and distinctively functionalized unsaturated 4-keto esters is developed for the construction of polycyclic bridged 2-chromanol lactones. Following this simple and facile protocol, a broad range of products was prepared in good to excellent yields as a single diastereomer. An unusual conglomerate (enantiomerically pure polymorph) of 3ac is reported along with the absolute stereochemistry, and the remaining products were rigorously confirmed by single-crystal X-ray analysis and analogy.</p>
1 aBorade, Balasaheb, R.1 aNomula, Rajesh1 aGonnade, Rajesh, G.1 aKontham, Ravindar  uhttps://library.ncl.res.in/content/feiii-catalyzed-diastereoselective-friedel-crafts-alkylation-hemiketalization-lactonization