01189nas a2200157   4500008004100000022001400041245009100055210006900146260000800215300001400223490000600237520062400243100002400867700002400891856011600915       2017                        eng d  a2470-134300aTotal synthesis of (+/-)-allocolchicine and its analogues using Co-catalyzed alkyne [20 aTotal synthesis of allocolchicine and its analogues using Cocata  cSEP  a5591-56000 v23 a<p>The total synthesis of (+/-)-allocolchicine has been completed by employing cobalt-catalyzed alkyne [2 + 2 + 2]-cyclotrimerization as the key reaction. The essential diyne has been synthesized from easily available 3,4,5-trimethoxybenzaldehyde following simple chemical transformations. In general, the cycloaddition gave a mixture of C(9) and C(10) isomers thus allowing the synthesis of both allocolchicine and its C(10)-carboxylate. Because this cycloaddition was employed at the penultimate stage, it allowed the synthesis of various analogues having the diverse functionality at C(9) and/or C(10) of ring C.</p>1 aPaymode, Dinesh, J.1 aRamana, Chepuri, V.  uhttps://library.ncl.res.in/content/total-synthesis-allocolchicine-and-its-analogues-using-co-catalyzed-alkyne-2