01610nas a2200193   4500008004100000022001400041245008600055210006900141260000900210300001400219490000700233520095900240100002401199700001601223700003001239700001701269700002001286856011001306       2017                        eng d  a1477-922600aRatiometric sensor for DNA based on a dual emission Ru(dppz) light-switch complex0 aRatiometric sensor for DNA based on a dual emission Rudppz light  cMAY   a6079-60860 v463 a<p>Herein we describe the DNA binding properties of two new water-soluble ruthenium complexes; experimental and computational data reveal that both complexes display dual emission from MLCT and LLCT excited states. The interaction of the new complexes with DNA was also investigated. Although one of the complexes only binds DNA though groove binding, the second complex has separate ligands capable of groove binding and intercalation. Nevertheless, it was found that both complexes interact with duplex DNA with high affinity. DNA induced distinctive changes in the emission of the complexes; although the groove binding complex only displays a modest increase in emission on binding, the complex that contains the intercalating Ru-II(dppz) moiety displays a large increase in MLCT-based emission on DNA binding while emission from the LLCT excited state is unaffected. This means that the complex functions as the first ratiometric sensor for DNA.</p>1 aWalker, Michael, G.1 aRamu, Vadde1 aMeijer, Anthony, J. H. M.1 aDas, Amitava1 aThomas, Jim, A.  uhttps://library.ncl.res.in/content/ratiometric-sensor-dna-based-dual-emission-rudppz-light-switch-complex